Structure of PDB 1t63 Chain A

Receptor sequence
>1t63A (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKW
AKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDL
VFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPV
DGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP
IARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB1t63 The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.
ChainA
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 V730 D731 M734 Q738 E893 M894 E897 V901 V48 K52 V62 D63 M66 Q70 E225 M226 E229 V233
BS02 DHT A L704 N705 Q711 M749 F764 T877 L36 N37 Q43 M81 F96 T209 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
External links
PDB RCSB:1t63, PDBe:1t63, PDBj:1t63
PDBsum1t63
PubMed15563469
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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