Structure of PDB 1t5p Chain A

Receptor sequence
>1t5pA (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
PQDLSEALKEATKEVHTQAENATRDGFKLVMASLYHIYVALEEEIERNKE
SPVFAPVYFPEELHRKAALEQDLAFWYGPRWQEVIPYTPAMQRYVKRLHE
VGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSSGEGLAFFTFP
NIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQEL
LTH
3D structure
PDB1t5p Human heme oxygenase oxidation of 5- and 15-phenylhemes.
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) N30 Y58 T135 R136 G139 D140 G144
Catalytic site (residue number reindexed from 1) N21 Y38 T115 R116 G119 D120 G124
Enzyme Commision number 1.14.14.18: heme oxygenase (biliverdin-producing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1FH A K18 H25 Q27 Y134 T135 G139 S142 L147 R183 F207 N210 K9 H16 Q18 Y114 T115 G119 S122 L127 R163 F187 N190
Gene Ontology
Molecular Function
GO:0004392 heme oxygenase (decyclizing) activity
Biological Process
GO:0006788 heme oxidation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1t5p, PDBe:1t5p, PDBj:1t5p
PDBsum1t5p
PubMed15297453
UniProtP09601|HMOX1_HUMAN Heme oxygenase 1 (Gene Name=HMOX1)

[Back to BioLiP]