Structure of PDB 1t4e Chain A

Receptor sequence
>1t4eA (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
GSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKR
LYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB1t4e Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DIZ A G16 L54 G58 I61 M62 V93 H96 Y100 G1 L39 G43 I46 M47 V78 H81 Y85 PDBbind-CN: -logKd/Ki=7.10,Kd=80nM
BindingDB: IC50=420nM,Kd=80nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1t4e, PDBe:1t4e, PDBj:1t4e
PDBsum1t4e
PubMed15715460
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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