Structure of PDB 1t3n Chain A

Receptor sequence
>1t3nA (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGN
YDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK
3D structure
PDB1t3n Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K207 P240 G241 I242 G243 K245 T246 S359 R360 Q361 C362 P363 K181 P214 G215 I216 G217 K219 T220 S333 R334 Q335 C336 P337
BS02 dna A R103 Q300 S301 S303 E304 E305 R331 R77 Q274 S275 S277 E278 E279 R305
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1t3n, PDBe:1t3n, PDBj:1t3n
PDBsum1t3n
PubMed15254543
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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