Structure of PDB 1t39 Chain A

Receptor sequence
>1t39A (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
CEMKRTTLDSPLGKLELSGCEQGLHEIKLLGPEPLMQCTAWLNAYFHQPE
AIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNP
KAARAVGGAMRGNPVPILIPCHRVVCSSGAVGNYSGGLAVKEWLLAHEGH
R
3D structure
PDB1t39 DNA binding and nucleotide flipping by the human DNA repair protein AGT.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.63: methylated-DNA--[protein]-cysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y114 Q115 R128 R135 C145 C150 S151 N157 Y158 Y90 Q91 R104 R111 C121 C126 S127 N133 Y134
BS02 dna A S93 F94 T95 N123 K125 A126 R128 A129 S69 F70 T71 N99 K101 A102 R104 A105
BS03 dna A N67 H71 Q72 N43 H47 Q48
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1t39, PDBe:1t39, PDBj:1t39
PDBsum1t39
PubMed15221026
UniProtP16455|MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase (Gene Name=MGMT)

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