Structure of PDB 1t38 Chain A

Receptor sequence
>1t38A (length=151) Species: 9606 (Homo sapiens) [Search protein sequence]
EMKRTTLDSPLGKLELSGCEQGLHEIKLLGPEPLMQCTAWLNAYFHQPEA
IEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYQQLAALAGNPK
AARAVGGAMRGNPVPILIPSHRVVCSSGAVGNYSGGLAVKEWLLAHEGHR
L
3D structure
PDB1t38 DNA binding and nucleotide flipping by the human DNA repair protein AGT.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.63: methylated-DNA--[protein]-cysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y114 R128 M134 S145 V148 C150 S151 N157 Y158 S159 K165 Y89 R103 M109 S120 V123 C125 S126 N132 Y133 S134 K140
BS02 dna A F94 T95 N123 K125 A126 R128 A129 F69 T70 N98 K100 A101 R103 A104
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1t38, PDBe:1t38, PDBj:1t38
PDBsum1t38
PubMed15221026
UniProtP16455|MGMT_HUMAN Methylated-DNA--protein-cysteine methyltransferase (Gene Name=MGMT)

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