Structure of PDB 1t2k Chain A

Receptor sequence
>1t2kA (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
TPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFG
IFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHD
PHKIYEFVNS
3D structure
PDB1t2k Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W38 H40 G41 L42 P74 K77 R81 K105 W36 H38 G39 L40 P72 K75 R79 K103
BS02 dna A K5 R7 I8 H40 L42 R43 Q44 W57 R78 N79 S82 K87 K98 K3 R5 I6 H38 L40 R41 Q42 W55 R76 N77 S80 K85 K96
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1t2k, PDBe:1t2k, PDBj:1t2k
PDBsum1t2k
PubMed15510218
UniProtQ14653|IRF3_HUMAN Interferon regulatory factor 3 (Gene Name=IRF3)

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