Structure of PDB 1t2c Chain A

Receptor sequence
>1t2cA (length=315) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
APKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHT
NVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPL
NNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLG
GVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQ
EFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYL
KDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAK
FDEAIAETKRMKALA
3D structure
PDB1t2c Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity.
ChainA
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R109 D168 R171 H195
Catalytic site (residue number reindexed from 1) R94 D154 R157 H181
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A G29 M30 I31 F52 D53 T97 A98 G99 F100 V138 N140 V142 L163 L167 H195 G12 M13 I14 F33 D34 T78 A79 G80 F81 V124 N126 V128 L149 L153 H181
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1t2c, PDBe:1t2c, PDBj:1t2c
PDBsum1t2c
PubMed15117937
UniProtQ27743|LDH_PLAFD L-lactate dehydrogenase

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