Structure of PDB 1szr Chain A

Receptor sequence
>1szrA (length=345) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]
GDPFFVADLGDIVRKHETWKKCLPRVTPFYAVKCNDDWRVLGTLAALGTG
FDCASNTEIQRVRGIGVPPEKIIYANPCKQISHIRYARDSGVDVMTFDCV
DELEKVAKTHPKAKMVLRISTGAKVEDCRFILEQAKKLNIDVTGVSFHVG
SGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGGFPGTRDAPLKFE
EIAGVINNALEKHFPPDLKLTIVAEPGRYYVASAFTLAVNVIAKAVTQSF
MYYVNDGVYGSFNCILYDHAVVRPLPQREPIPNEKLYPSSVWGPTCDGLD
QIVERYYLPEMQVGEWLLFEDMGAYTVVGTSSFNGFQSPTIYYVV
3D structure
PDB1szr Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K33 H148 E225
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLG A K69 H197 G237 E274 G276 R277 Y389 K33 H148 G188 E225 G227 R228 Y325
BS02 ORX A C360 D361 C296 D297
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0033387 putrescine biosynthetic process from ornithine
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1szr, PDBe:1szr, PDBj:1szr
PDBsum1szr
PubMed15476392
UniProtP07805|DCOR_TRYBB Ornithine decarboxylase

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