Structure of PDB 1szf Chain A

Receptor sequence
>1szfA (length=395) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
GETKEDIARKEQLKSLLPPLDNIINLYDFEYLASQTLTKQAWAYYSSGAN
DEVTHRENHNAYHRIFFKPKILVDVRKVDISTDMLGSHVDVPFYVSATGL
CKLGNPLEGEKDVARGCGQGVTKVPQMISTAASCSPEEIIEAAPSDKQIQ
WYQLYVNSDRKITDDLVKNVEKLGVKALFVTVDAPSLGQREKDMKLKFSN
GASRALSKFIDPSLTWKDIEELKKKTKLPIVIKGVQRTEDVIKAAEIGVS
GVVLSNHGGRQLDFSRAPIEVLAETMPILEQRNLKDKLEVFVDGGVRRGT
DVLKALCLGAKGVGLGRPFLYANSCYGRNGVEKAIEILRDEIEMSMRLLG
VTSIAELKPDLLDLSTLKARTVGVPNDVLYNEVYEGPTLTEFEDA
3D structure
PDB1szf Altered Substrate Specificity in Flavocytochrome b(2): Structural Insights into the Mechanism of l-Lactate Dehydrogenation
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S228 Y254 T280 D282 K349 H373
Catalytic site (residue number reindexed from 1) S129 Y155 T181 D183 K233 H257
Enzyme Commision number 1.1.2.3: L-lactate dehydrogenase (cytochrome).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A Y144 S195 A196 T197 G198 Q252 Y254 T280 K349 H373 G374 R376 D409 G410 R413 G432 R433 Y45 S96 A97 T98 G99 Q153 Y155 T181 K233 H257 G258 R260 D293 G294 R297 G316 R317
BS02 PYR A Y143 Y254 H373 R376 Y44 Y155 H257 R260
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:1szf, PDBe:1szf, PDBj:1szf
PDBsum1szf
PubMed15260495
UniProtP00175|CYB2_YEAST L-lactate dehydrogenase (cytochrome) (Gene Name=CYB2)

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