Structure of PDB 1sto Chain A

Receptor sequence
>1stoA (length=208) [Search protein sequence]
MKPYQRQFIEFALNKQVLKFGEFTLKSGRKSPYFFNAGLFNTGRDLALLG
RFYAEALVDSGIEFDLLFGPAYKGIPIATTTAVALAEHHDKDLPYCFNRK
AAGGSLVGSALQGRVMLVDDVITAGTAIRESMEIIQAHGATLAGVLISLD
RQERGRGEISAIQEVERDYGCKVISIITLKDLIAYLEEKPDMAEHLAAVR
AYREEFGV
3D structure
PDB1sto Crystal structure of orotate phosphoribosyltransferase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.10: orotate phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OMP A L25 K26 F34 F35 V126 I127 T128 A129 T131 R156 L25 K26 F34 F35 V121 I122 T123 A124 T126 R151
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004588 orotate phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1sto, PDBe:1sto, PDBj:1sto
PDBsum1sto
PubMed8312245
UniProtP08870|PYRE_SALTY Orotate phosphoribosyltransferase (Gene Name=pyrE)

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