Structure of PDB 1ssa Chain A

Receptor sequence

>1ssaA (length=113) Species: 9913 (Bos taurus)

KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES
LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT
QANKHIIVACEGN

3D structure

• PDB: 1ssa Structural investigation of catalytically modified F120L and F120Y semisynthetic ribonucleases.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H12 K41
• Catalytic site (residue number reindexed from 1): H12 K41
• Enzyme Commision number: 4.6.1.18: pancreatic ribonuclease.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	F8 Q55 C58 K66 Y73 K104 H105 I107 V108 A109 C110 E111 G112 N113	F8 Q55 C58 K66 Y73 K104 H105 I107 V108 A109 C110 E111 G112 N113

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0004519 endonuclease activity
• GO:0004522 ribonuclease A activity
• GO:0004540 RNA nuclease activity
• GO:0005515 protein binding
• GO:0016829 lyase activity

Biological Process

• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1ssa, PDBe:1ssa, PDBj:1ssa
• PDBsum: 1ssa
• PubMed: 8142897
• UniProt: P61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)