Structure of PDB 1sqn Chain A

Receptor sequence

>1sqnA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]

QLIPPLINLLMSIEPDVIYAGHDNPDTSSSLLTSLNQLGERQLLSVVKWS
KSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLI
LNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLE
GLRSQTQFEEMRSSYIRELIKAIGLRQGVVSSSQRFYQLTKLLDNLHDLV
KQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK

3D structure

PDB

1sqn Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes

Chain

Resolution

1.451 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NDR	A	L718 L721 Q725 M759 Y890 C891	L35 L38 Q42 M76 Y206 C207	MOAD: Kd=0.4nM PDBbind-CN: -logKd/Ki=9.40,Kd=0.4nM BindingDB: Kd=0.4nM,Ki=1.9nM,IC50=3.2nM,EC50=2.2nM

External links

PDB	RCSB:1sqn, PDBe:1sqn, PDBj:1sqn
PDBsum	1sqn
PubMed	15189034
UniProt	P06401\|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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