Structure of PDB 1sqk Chain A

Receptor sequence

>1sqkA (length=360) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGKDSYVGDEAQSK
RGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLN
PKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTH
NVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRD
IKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETL
FQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIAD
RMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQE
YDEAGPSIVH

3D structure

PDB

1sqk The beta-Thymosin/WH2 Domain; Structural Basis for the Switch from Inhibition to Promotion of Actin Assembly

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	G23 D24 D25 Y143 T148 E167 Y169 I345 L349 T351 M355	G19 D20 D21 Y132 T137 E156 Y158 I334 L338 T340 M344
BS02	ADP	A	G13 S14 G15 L16 K18 G156 D157 G182 R210 K213 E214 G302 Y306	G9 S10 G11 L12 K14 G145 D146 G171 R199 K202 E203 G291 Y295
BS03	LAR	A	G15 L16 P32 Q59 Y69 D157 G182 R183 T186 R206 E207 R210	G11 L12 P28 Q48 Y58 D146 G171 R172 T175 R195 E196 R199

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003785	actin monomer binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005523	tropomyosin binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0019904	protein domain specific binding
GO:0031013	troponin I binding
GO:0031432	titin binding
GO:0032036	myosin heavy chain binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0140660	cytoskeletal motor activator activity

	Biological Process
GO:0010628	positive regulation of gene expression
GO:0030041	actin filament polymerization
GO:0030240	skeletal muscle thin filament assembly
GO:0048741	skeletal muscle fiber development
GO:0051017	actin filament bundle assembly
GO:0090131	mesenchyme migration

	Cellular Component
GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005865	striated muscle thin filament
GO:0005884	actin filament
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0031941	filamentous actin
GO:0032432	actin filament bundle
GO:0044297	cell body
GO:0098723	skeletal muscle myofibril

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1sqk, PDBe:1sqk, PDBj:1sqk
PDBsum	1sqk
PubMed	15163409
UniProt	P68135\|ACTS_RABIT Actin, alpha skeletal muscle (Gene Name=ACTA1)

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