Structure of PDB 1sq5 Chain A

Receptor sequence
>1sq5A (length=302) Species: 562 (Escherichia coli) [Search protein sequence]
MTPYLQFDRNQWAALRDMLSEDEIARLKGINEDLSLEEVAEIYLPLSRLL
NFYISSNLRRQAVLEQFLGTNQRIPYIISIAGSVAVGKSTTARVLQALLS
RWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDL
KSGVPNVTAPVYSHLIYDVIPDGDKTVVPDILILEGLNVLQSGMDYPHDP
HHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNYAK
LTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLILTKSANHAVEEVRL
RK
3D structure
PDB1sq5 The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAU A D1127 K1145 H1177 Y1240 I1281 N1282 D114 K132 H164 Y226 I267 N268
BS02 ADP A N1043 A1098 G1100 K1101 S1102 T1103 R1243 K1303 H1307 N31 A85 G87 K88 S89 T90 R229 K289 H293
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0050165 pantetheine kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1sq5, PDBe:1sq5, PDBj:1sq5
PDBsum1sq5
PubMed15136582
UniProtP0A6I3|COAA_ECOLI Pantothenate kinase (Gene Name=coaA)

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