Structure of PDB 1snk Chain A

Receptor sequence
>1snkA (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
PDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQ
NLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPT
GKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYY
DESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKN
NACGIANLASFPKM
3D structure
PDB1snk Exploration of the P(2)-P(3) SAR of aldehyde cathepsin K inhibitors
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q18 C24 H161 N181
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYE A G23 C25 N60 D61 G65 G66 Y67 L160 H162 G22 C24 N59 D60 G64 G65 Y66 L159 H161 PDBbind-CN: -logKd/Ki=9.60,IC50=0.25nM
BindingDB: IC50=0.250000nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1snk, PDBe:1snk, PDBj:1snk
PDBsum1snk
PubMed15177446
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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