Structure of PDB 1snf Chain A

Receptor sequence
>1snfA (length=131) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
STTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAV
AVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAA
PIVVHRGDRIAQLLVQRVELVELVEVSSFDE
3D structure
PDB1snf Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A25 R64 G66 L73 D83
Catalytic site (residue number reindexed from 1) A24 R63 G65 L72 D82
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A N77 G80 T81 I82 D83 Y86 K91 N76 G79 T80 I81 D82 Y85 K90
BS02 UMP A R64 S65 R63 S64
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0009117 nucleotide metabolic process
GO:0046080 dUTP metabolic process
GO:0046081 dUTP catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1snf, PDBe:1snf, PDBj:1snf
PDBsum1snf
PubMed15276840
UniProtP9WNS5|DUT_MYCTU Deoxyuridine 5'-triphosphate nucleotidohydrolase (Gene Name=dut)

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