Structure of PDB 1sl3 Chain A

Receptor sequence
>1sl3A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
DCGLRPLFEKKSLEDKTERELLESYIIVEGSDAEIGMSPWQVMLFRKSPQ
ELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERN
IEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRE
TAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIVERPVCKDSTRIRIT
DNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCD
RDGKYGFYTHVFRLKKWIQKVIDQFG
3D structure
PDB1sl3 Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors
ChainA
Resolution1.81 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H69 D125 E220 G221 D222 S223 G224
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F34 Q38 E39 L40 R73 T74 R75 Y76 I82 F45 Q50 E51 L52 R94 T95 R96 Y97 I104
BS02 170 A H57 Y60B W60E N98 L99 I174 A190 C191 S195 V213 S214 W215 G216 C220 G226 F227 H69 Y73 W76 N121 L122 I197 A218 C219 S223 V243 S244 W245 G246 C249 G256 F257 MOAD: Ki=1.4pM
PDBbind-CN: -logKd/Ki=11.85,Ki=1.4pM
BindingDB: Ki=0.001400nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1sl3, PDBe:1sl3, PDBj:1sl3
PDBsum1sl3
PubMed15163182
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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