Structure of PDB 1skx Chain A

Receptor sequence
>1skxA (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
LTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVKVSLQLRGEDGSVWN
YKPPIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAF
ELCQLRFNTVFNAETGTWECGRLSYCLELLLEPMLKFHYMLKKLQLHEEE
YVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFL
FLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGI
3D structure
PDB1skx Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RFP A K210 V211 L240 M243 S247 C284 Q285 F288 W299 L308 H407 F420 K36 V37 L59 M62 S66 C103 Q104 F107 W118 L127 H218 F231 BindingDB: EC50=3500nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1skx, PDBe:1skx, PDBj:1skx
PDBsum1skx
PubMed15705662
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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