Structure of PDB 1skj Chain A

Receptor sequence
>1skjA (length=102) Species: 11886 (Rous sarcoma virus) [Search protein sequence]
EEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAK
GLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVC
PT
3D structure
PDB1skj Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UR2 A R32 S34 T36 C42 H58 Y59 K60 I71 G93 R30 S32 T34 C40 H56 Y57 K58 I69 G91 MOAD: ic50=7uM
PDBbind-CN: -logKd/Ki=5.15,IC50=7.0uM
External links
PDB RCSB:1skj, PDBe:1skj, PDBj:1skj
PDBsum1skj
PubMed9371236
UniProtP00524|SRC_RSVSA Tyrosine-protein kinase transforming protein Src (Gene Name=V-SRC)

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