Structure of PDB 1sj0 Chain A

Receptor sequence
>1sj0A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCVVPLYDLLLEMLDAHRLHA
3D structure
PDB1sj0 Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E4D A M343 L346 T347 A350 D351 E353 W383 L387 F404 G521 H524 L525 C530 M37 L40 T41 A44 D45 E47 W77 L81 F98 G215 H218 L219 C224 MOAD: ic50=0.8nM
PDBbind-CN: -logKd/Ki=9.10,IC50=0.8nM
BindingDB: IC50=0.8nM
External links
PDB RCSB:1sj0, PDBe:1sj0, PDBj:1sj0
PDBsum1sj0
PubMed15084115
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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