Structure of PDB 1shl Chain A

Receptor sequence
>1shlA (length=198) Species: 9606 (Homo sapiens) [Search protein sequence]
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGF
DVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGV
TPIKDLTAHFRGDRCKTLLEKPKLFFIQACIPVEADFLFAYSTVRGSWFV
QALCSILEEHGKDLEIMQILTRVNDRVARHFQIPCVVSMLTKELYFSQ
3D structure
PDB1shl Discovery of an allosteric site in the caspases
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G29 V30 H88 G89 C130
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FXN A F221 Y223 V292 F139 Y141 V187
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1shl, PDBe:1shl, PDBj:1shl
PDBsum1shl
PubMed15314233
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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