Structure of PDB 1sh3 Chain A

Receptor sequence
>1sh3A (length=502) Species: 11983 (Norwalk virus) [Search protein sequence]
GTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRVKG
GPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDKWS
FAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEEGK
NMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLMDE
LKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRAVL
AAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPCT
SQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKLDP
EKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWFGK
LEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPAFY
SKISKLVIAELKEGGMDFYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
ED
3D structure
PDB1sh3 Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D240 D344 T389 D235 D339 T384
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1sh3, PDBe:1sh3, PDBj:1sh3
PDBsum1sh3
PubMed14764591
UniProtQ70ET3

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