Structure of PDB 1sez Chain A

Receptor sequence

>1sezA (length=465) Species: 4097 (Nicotiana tabacum)

AKRVAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGKLRSVSQDGLIW
DEGANTMTESEGDVTFLIDSLGLREKQQFPLSQNKRYIARNGTPVLLPSN
PIDLIKSNFLSTGSKLQMLLEPILWSHESVSGFFQRHFGKEVVDYLIDPF
VAGTCGGDPDSLSMHHSFPELWNLEKRFGSVILGAIRSKLSKTSANKKRQ
RGSFSFLGGMQTLTDAICKDLREDELRLNSRVLELSCSCTEDSAIDSWSI
ISASPHKRQSEEESFDAVIMTAPLCDVKSMKIAKRGNPFLLNFIPEVDYV
PLSVVITTFKRENVKYPLEGFGVLVPSKEQQHGLKTLGTLFSSMMFPDRA
PNNVYLYTTFVGGSRNRELAKASRTELKEIVTSDLKQLLGAEGEPTYVNH
LYWSKAFPLYGHNYDSVLDAIDKMEKNLPGLFYAGNHRGGLSVGKALSSG
CNAADLVISYLESVS

3D structure

• PDB: 1sez Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis.
• Chain: A
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 1.3.3.4: protoporphyrinogen oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	I19 G20 G22 S24 E43 A44 G50 K51 G65 A66 T68 R263 V264 A304 D308 A438 F439 S474 V475	I7 G8 G10 S12 E31 A32 G38 K39 G53 A54 T56 R231 V232 A272 D276 A406 F407 S442 V443
BS02	OMN	A	R98 A174 G175 G178 G354 L356 L369 G370 T371 L372 F392	R86 A152 G153 G156 G322 L324 L337 G338 T339 L340 F360
BS03	TON	A	R98 L109 F172	R86 L97 F150

Gene Ontology

Molecular Function

• GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006779 porphyrin-containing compound biosynthetic process
• GO:0006782 protoporphyrinogen IX biosynthetic process
• GO:0006783 heme biosynthetic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane

External links

• PDB: RCSB:1sez, PDBe:1sez, PDBj:1sez
• PDBsum: 1sez
• PubMed: 15057273
• UniProt: O24164|PPOM_TOBAC Protoporphyrinogen oxidase, mitochondrial (Gene Name=PPXII)