Structure of PDB 1sa1 Chain A

Receptor sequence
>1sa1A (length=433) Species: 9913 (Bos taurus) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDGDDSFNTFFSET
GAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARG
HYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMER
LSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDN
EAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQ
TNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCD
PRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGIN
YEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVH
WYVGEGMEEGEFSEAREDMAALEKDYEEVGVDS
3D structure
PDB1sa1 Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
ChainA
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A G144 T145 G138 T139
BS02 GTP A G10 Q11 A12 E71 A99 S140 G142 G143 G144 T145 E183 N206 Y224 N228 G9 Q10 A11 E65 A93 S134 G136 G137 G138 T139 E177 N200 Y218 N222
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1sa1, PDBe:1sa1, PDBj:1sa1
PDBsum1sa1
PubMed15014504
UniProtQ2HJ86|TBA1D_BOVIN Tubulin alpha-1D chain (Gene Name=TUBA1D)

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