Structure of PDB 1s9i Chain A

Receptor sequence
>1s9iA (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
QKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKP
AIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVL
KEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIK
LCDFGVSGQLIDSMVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVG
RYPIPPPDAKELEAIFGRPVVDRPAMAIFELLDYIVNEPPPKLPNGVFTP
DFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLN
QPG
3D structure
PDB1s9i Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D194 K196 S198 N199 D212 D221 T230
Catalytic site (residue number reindexed from 1) D135 K137 S139 N140 D153 D162 T167
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N199 D212 N140 D153
BS02 ATP A G81 N82 V86 A99 K101 M147 M150 S154 Q157 K196 S198 L201 G22 N23 V27 A40 K42 M88 M91 S95 Q98 K137 S139 L142
BS03 5EA A N82 L122 V131 M147 D194 D212 F213 G214 V215 S216 I220 M223 N23 L63 V72 M88 D135 D153 F154 G155 V156 S157 I161 M164
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s9i, PDBe:1s9i, PDBj:1s9i
PDBsum1s9i
PubMed15543157
UniProtP36507|MP2K2_HUMAN Dual specificity mitogen-activated protein kinase kinase 2 (Gene Name=MAP2K2)

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