Structure of PDB 1s70 Chain A

Receptor sequence
>1s70A (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
HMADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQP
ILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQS
LETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWK
TFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGL
LCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQV
VEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSE
KKAKYQYGG
3D structure
PDB1s70 Structural basis of protein phosphatase 1 regulation
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Catalytic site (residue number reindexed from 1) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
3.1.3.53: [myosin-light-chain] phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D92 N124 H173 H248 D92 N124 H173 H248
BS02 MN A D64 H66 D92 H125 D64 H66 D92 H125
Gene Ontology
Molecular Function
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0017018 myosin phosphatase activity
GO:0046872 metal ion binding
GO:0050115 myosin-light-chain-phosphatase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0030155 regulation of cell adhesion
GO:0032922 circadian regulation of gene expression
GO:0042752 regulation of circadian rhythm
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0072357 PTW/PP1 phosphatase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s70, PDBe:1s70, PDBj:1s70
PDBsum1s70
PubMed15164081
UniProtP62207|PP1B_CHICK Serine/threonine-protein phosphatase PP1-beta catalytic subunit (Gene Name=PPP1CB)

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