Structure of PDB 1s5o Chain A

Receptor sequence
>1s5oA (length=591) Species: 9606 (Homo sapiens) [Search protein sequence]
HHTDPLPRLPVPPLQQSLDHYLKALQPIVSEEEWAHTKQLVDEFQASGGV
GERLQKGLERRARKTENWLSEWWLKTAYLQYRQPVVIYSSPGVMLPKQDF
VDLQGQLRFAAKLIEGVLDFKVMIDNETLPVEYLGGKPLCMNQYYQILSS
CRVPGPKQDTVSNFSKTKKPPTHITVVHNYQFFELDVYHSDGTPLTADQI
FVQLEKIWNSSLQTNKEPVGILTSNHRNSWAKAYNTLIKDKVNRDSVRSI
QKSIFTVCLDATMPRVSEDVYRSHVAGQMLHGGGSRLNSGNRWFDKTLQF
IVAEDGSCGLVYEHAAAEGPPIVTLLDYVIEYTKKPELVRSPMVPLPMPK
KLRFNITPEIKSDIEKAKQNLSIMIQDLDITVMVFHHFGKDFPKSEKLSP
DAFIQMALQLAYYRIYGQACATYESASLRMFHLGRTDTIRSASMDSLTFV
KAMDDSSVTEHQKVELLRKAVQAHRGYTDRAIRGEAFDRHLLGLKLQAIE
DLVSTPDIFMDTSYAIAMHFHLSTSQVPAKTDCVMFFGPVVPDGYGVCYN
PMEAHINFSLSAYNSCAETNAARLAHYLEKALLDMRALLQS
3D structure
PDB1s5o Structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y86 P99 H322 S533
Catalytic site (residue number reindexed from 1) Y78 P91 H314 S525
Enzyme Commision number 2.3.1.137: carnitine O-octanoyltransferase.
2.3.1.7: carnitine O-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 152 A H322 Y431 S433 T444 S531 F545 H314 Y423 S425 T436 S523 F537
Gene Ontology
Molecular Function
GO:0003997 acyl-CoA oxidase activity
GO:0004092 carnitine O-acetyltransferase activity
GO:0008458 carnitine O-octanoyltransferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0019254 carnitine metabolic process, CoA-linked
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase
GO:0046459 short-chain fatty acid metabolic process
GO:0051791 medium-chain fatty acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s5o, PDBe:1s5o, PDBj:1s5o
PDBsum1s5o
PubMed15099582
UniProtP43155|CACP_HUMAN Carnitine O-acetyltransferase (Gene Name=CRAT)

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