Structure of PDB 1s50 Chain A

Receptor sequence
>1s50A (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTY
EIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVID
FSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSK
ISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQR
NCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKW
WRGNGCPE
3D structure
PDB1s50 Crystal structures of the GluR5 and GluR6 ligand binding cores: Molecular mechanisms underlying kainate receptor selectivity
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A Y61 P89 L90 A91 R96 G141 A142 T143 E191 Y60 P88 L89 A90 R95 G140 A141 T142 E190 MOAD: Ki=1.4uM
PDBbind-CN: -logKd/Ki=7.20,Ki=0.063uM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1s50, PDBe:1s50, PDBj:1s50
PDBsum1s50
PubMed15721240
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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