Structure of PDB 1s4d Chain A

Receptor sequence
>1s4dA (length=256) Species: 43306 (Pseudomonas denitrificans (nom. rej.)) [Search protein sequence]
FAGLPALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNEDCL
KLARPGAVLEFAGKRGPSPKQRDISLRLVELARAGNRVLRLKGGDPFVFG
RGGEEALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVTFLTG
HDRINWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPDEPVAFVCNAA
TPQQAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAALDWIGALDGR
KLAADP
3D structure
PDB1s4d Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D47 K69 M184
Catalytic site (residue number reindexed from 1) D42 K64 M170
Enzyme Commision number 2.1.1.107: uroporphyrinogen-III C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A G100 G101 D102 V105 T130 A131 Y183 M184 N212 A213 P240 A241 I242 G93 G94 D95 V98 T123 A124 Y169 M170 N198 A199 P226 A227 I228 PDBbind-CN: -logKd/Ki=6.49,Ki=0.32uM
Gene Ontology
Molecular Function
GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s4d, PDBe:1s4d, PDBj:1s4d
PDBsum1s4d
PubMed15522295
UniProtP21631|SUMT_SINSX Uroporphyrinogen-III C-methyltransferase (Gene Name=cobA)

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