Structure of PDB 1s49 Chain A

Receptor sequence
>1s49A (length=588) Species: 11099 (Bovine viral diarrhea virus 1) [Search protein sequence]
VIREHNKWILKKIRFQGNLNTKKMLNPGKLSEQLDREGRKRNIYNHQIGT
IMSSAGIRLEKLPIVRAQTDTKTFHEAIRDKIDKSENRQNPELHNKLLEI
FHTIAQPTLKHTYGEVTWEQLEAGVNRKGAAGFLEKKNIGEVLDSEKHLV
EQLVRDLKAGRKIKYYETAIPKNEKRDVSDDWQAGDLVVEKRPRVIQYPE
AKTRLAITKVMYNWVKQQPVVIPGYEGKTPLFNIFDKVRKEWDSFNEPVA
VSFDTKAWDTQVTSKDLQLIGEIQKYYYKKEWHKFIDTITDHMTEVPVIT
ADGEVYIRNGQRGSGQPDTSAGNSMLNVLTMMYAFCESTGVPYKSFNRVA
RIHVCGDDGFLITEKGLGLKFANKGMQILHEAGKPQKITEGEKMKVAYRF
EDIEFCSHTPVPVRWSDNTSSHMAGRDTAVILSKMATRLDSSGERGTTAY
EKAVAFSFLLMYSWNPLVRRICLLVLSQQPETDPSKHATYYYKGDPIGAY
KDVIGRNLSELKRTGFEKLANLNLSLSTLGVWTKHTSKRIIQDCVAIGKE
EGNWLVKPDRLISSKTGHLYIPDKGFTLQGKHYEQLQL
3D structure
PDB1s49 The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.113: pestivirus NS3 polyprotein peptidase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
4.6.1.19: ribonuclease T2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A T320 L322 C497 R517 K525 R529 L677 T229 L231 C406 R426 K434 R438 L586
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1s49, PDBe:1s49, PDBj:1s49
PDBsum1s49
PubMed15070734
UniProtP19711|POLG_BVDVN Genome polyprotein

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