Structure of PDB 1s3i Chain A

Receptor sequence
>1s3iA (length=307) Species: 10116 (Rattus norvegicus) [Search protein sequence]
MKIAVIGQSLFGQEVYCQLRKEGHEVVGVFTIPDKDGKADPDGLEAEKDG
VPVFKFPRWRARGQALPEVVAKYQALGAELNVLPFCSQFIPMEVINAPRH
GSIIYHPSLLPRHRGASAINWTLIHGDKKGGFTIFWADDGLDTGDLLLQK
ECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGTAPRCPQSEEGATY
EGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACGQKLTFFNSTLN
TSGLSTQGEALPIPGAHRPGVVTKAGLILFGNDDRMLLVKNIQLEDGKMM
PASQFFK
3D structure
PDB1s3i The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H106 D142
Catalytic site (residue number reindexed from 1) H106 D142
Enzyme Commision number 1.5.1.6: formyltetrahydrofolate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BME A H106 G115 D142 H106 G115 D142
BS02 BME A T31 I32 F56 W59 C86 T31 I32 F56 W59 C86
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
Biological Process
GO:0009058 biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1s3i, PDBe:1s3i, PDBj:1s3i
PDBsum1s3i
PubMed14729668
UniProtP28037|AL1L1_RAT Cytosolic 10-formyltetrahydrofolate dehydrogenase (Gene Name=Aldh1l1)

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