Structure of PDB 1s26 Chain A

Receptor sequence
>1s26A (length=485) Species: 1392 (Bacillus anthracis) [Search protein sequence]
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKS
GVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSI
TEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQV
YEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTAD
YDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERK
PDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDN
EIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKA
YIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSSVKKIAGYLSDYYNSAN
HIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQ
VQLLLTHQKFKLLYKQLNFTENETDNFEVFQKIID
3D structure
PDB1s26 Structure of anthrax edema factor-calmodulin-adenosine-5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APC A K346 H351 S354 K372 K382 D493 N583 F586 K55 H60 S63 K81 K91 D202 N292 F295 PDBbind-CN: -logKd/Ki=3.07,Ki=0.85mM
Gene Ontology
Molecular Function
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1s26, PDBe:1s26, PDBj:1s26
PDBsum1s26
PubMed15063758
UniProtP40136|CYAA_BACAN Calmodulin-sensitive adenylate cyclase (Gene Name=cya)

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