Structure of PDB 1s19 Chain A

Receptor sequence
>1s19A (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
LRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSVTLE
LSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEV
IMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGL
KKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCR
HPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFG
3D structure
PDB1s19 Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MC9 A Y143 V234 S237 R274 S275 S278 W286 H305 H397 Y24 V64 S67 R104 S105 S108 W116 H135 H227 PDBbind-CN: -logKd/Ki=9.51,Kd=0.31nM
BindingDB: Kd=0.31nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1s19, PDBe:1s19, PDBj:1s19
PDBsum1s19
PubMed15055995
UniProtP11473|VDR_HUMAN Vitamin D3 receptor (Gene Name=VDR)

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