Structure of PDB 1s0x Chain A

Receptor sequence
>1s0xA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
HHLEVLFQGPAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIEN
YQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS
LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSL
CSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKN
HREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKEL
F
3D structure
PDB1s0x Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C3S A Q289 Y290 W320 M368 R370 Q29 Y30 W60 M108 R110
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1s0x, PDBe:1s0x, PDBj:1s0x
PDBsum1s0x
PubMed14722075
UniProtP35398|RORA_HUMAN Nuclear receptor ROR-alpha (Gene Name=RORA)

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