Structure of PDB 1s0u Chain A

Receptor sequence

>1s0uA (length=391) Species: 2190 (Methanocaldococcus jannaschii)

SQAEVNIGMVGHVDHGKTSLTKALTGVWTDRGISIRLGYADCEIRKCPQC
GTYTTKPRCPNCLAETEFLRRVSFVDSPGHETLMATMLSGASLMDGAILV
IAANEPCPQPQTKEHLMALEILGIDKIIIVQNKIDLVDEKQAEENYEQIK
EFVKGTIAENAPIIPINIDVLLKAIQDFIPTPKRDPDATPRMYVARSFDI
NKPGTEIKDLKGGVLGGAIIQGVFKVGDEIEIRPGIKVTEGNKTFWKPLT
TKIVSLAAGNTILRKAHPGGLIGVGTTLDPYLTKSDALTGSVVGLPGTLP
PIREKITIRANLLDRVVGTKEELKIEPLRTGEVLMLNIGTATTAGVITSA
RGDIADIKLKLPICAEIGDRVAISRRVGSRWRLIGYGTIEG

3D structure

• PDB: 1s0u X-ray Structure of Translation Initiation Factor eIF2gamma: IMPLICATIONS FOR tRNA AND eIF2alpha BINDING.
• Chain: A
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D47 K50 T51 S74 H120
• Catalytic site (residue number reindexed from 1): D14 K17 T18 S34 H80
• Enzyme Commision number: 3.6.5.3: protein-synthesizing GTPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C87 C90 C99	C47 C50 C59

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003743 translation initiation factor activity
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001731 formation of translation preinitiation complex
• GO:0006412 translation
• GO:0006413 translational initiation
• GO:0006414 translational elongation

External links

• PDB: RCSB:1s0u, PDBe:1s0u, PDBj:1s0u
• PDBsum: 1s0u
• PubMed: 14688270
• UniProt: Q58657|IF2G_METJA Translation initiation factor 2 subunit gamma (Gene Name=eif2g)