Structure of PDB 1rxv Chain A

Receptor sequence
>1rxvA (length=305) Species: 2234 (Archaeoglobus fulgidus) [Search protein sequence]
DIGDLFEREEVELEYFSGKKIAVDAFNTLYQFISIIRQPDGTPLKDSQGR
ITSHLSGILYRVSNMVEVGIRPVFVFDGEPPEFKKAEIEERKKRRAEAEE
MWIAALQAGDKDAKKYAQAAGRVDEYIVDSAKTLLSYMGIPFVDAPSEGE
AQAAYMAAKGDVEYTGSQDYDSLLFGSPRLARNLAIKPEIIILESNLKRL
GLTREQLIDIAILVGTDYNEGVKGVGVKKALNYIKTYGDIFRALKALKVN
IDHVEEIRNFFLNPPVTDDYRIEFREPDFEKAIEFLCEEHDFSRERVEKA
LEKLK
3D structure
PDB1rxv Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L47 K48 T55 H308 D309 F310 S311 R314 L44 K45 T52 H290 D291 F292 S293 R296
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0043137 DNA replication, removal of RNA primer

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Molecular Function
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Biological Process
External links
PDB RCSB:1rxv, PDBe:1rxv, PDBj:1rxv
PDBsum1rxv
PubMed14718165
UniProtO29975|FEN_ARCFU Flap endonuclease 1 (Gene Name=fen)

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