Structure of PDB 1rwx Chain A

Receptor sequence
>1rwxA (length=178) Species: 9606 (Homo sapiens) [Search protein sequence]
NPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC
NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA
HRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKN
CPSLKDKPKVIIIQACRGDSPGVVWFKD
3D structure
PDB1rwx Tethering identifies fragment that yields potent inhibitors of human caspase-1.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P177 R178 H237 G238 C285 R286
Catalytic site (residue number reindexed from 1) P58 R59 H118 G119 C166 R167
Enzyme Commision number 3.4.22.36: caspase-1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YBH A R179 H237 Q283 C285 R60 H118 Q164 C166 PDBbind-CN: -logKd/Ki=7.37,Ki=43nM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1rwx, PDBe:1rwx, PDBj:1rwx
PDBsum1rwx
PubMed16274992
UniProtP29466|CASP1_HUMAN Caspase-1 (Gene Name=CASP1)

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