Structure of PDB 1rqi Chain A

Receptor sequence
>1rqiA (length=300) Species: 562 (Escherichia coli) [Search protein sequence]
AMDFPQQLEACVKQANQALSRFIAPLPFQNTPVVETMQYGALLGGKRLRP
FLVYATGHMFGVSTNTLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGLP
TCHVKFGEANAILAGDALQTLAFSILSDADMPEVSDRDRISMISELASAS
GIAGMCGGQALDLDAEGKHVPLDALERIHRHKTGALIRAAVRLGALSAGD
KGRRALPVLDKYAESIGLAFQVQDDILDVVGDTATLGKRQGADQQLGKST
YPALLGLEQARKKARDLIDDARQSLKQLAEQSLDTSALEALADYIIQRNK
3D structure
PDB1rqi Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
ChainA
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D105 D111 D85 D91
BS02 MG A D105 D111 D85 D91
BS03 DST A S101 D105 R116 M175 Q179 K202 D244 K258 S81 D85 R96 M155 Q159 K182 D224 K238
BS04 IPR A G65 K66 R69 H98 R117 F240 D244 G45 K46 R49 H78 R97 F220 D224
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1rqi, PDBe:1rqi, PDBj:1rqi
PDBsum1rqi
PubMed14672944
UniProtP22939|ISPA_ECOLI Farnesyl diphosphate synthase (Gene Name=ispA)

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