Structure of PDB 1roz Chain A

Receptor sequence
>1rozA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
STQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPL
SQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDV
LVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYC
KFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKN
HIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTG
MIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSW
GKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFM
3D structure
PDB1roz A New Crystal Structure of Deoxyhypusine Synthase Reveals the Configuration of the Active Enzyme and of an Enzyme-NAD-Inhibitor Ternary Complex
ChainA
Resolution2.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E137 H288 K329
Catalytic site (residue number reindexed from 1) E110 H261 K302
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A T104 S105 N106 T131 A132 G133 D238 G282 G283 N307 T308 A309 D342 A343 T77 S78 N79 T104 A105 G106 D211 G255 G256 N280 T281 A282 D315 A316
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:1roz, PDBe:1roz, PDBj:1roz
PDBsum1roz
PubMed15100216
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

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