Structure of PDB 1rne Chain A

Receptor sequence
>1rneA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
NTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITV
TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLK
EDVFSFYYNRLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVG
SSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNE
GPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGP
TWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB1rne The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 N37 W39 Y75 D215 A218
Catalytic site (residue number reindexed from 1) D34 S37 N39 W41 Y79 D215 A218
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C60 A Q13 D32 G34 Y75 S76 T77 F117 D215 G217 A218 S219 Y220 S222 A300 Q15 D34 G36 Y79 S80 T81 F120 D215 G217 A218 S219 Y220 S222 A303 MOAD: ic50=2nM
PDBbind-CN: -logKd/Ki=8.70,IC50=2nM
BindingDB: IC50=0.830000nM,Ki=0.7nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1rne, PDBe:1rne, PDBj:1rne
PDBsum1rne
PubMed1807356
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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