Structure of PDB 1rkc Chain A

Receptor sequence
>1rkcA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAA
VSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPY
SVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEV
VETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKE
LLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQL
TSWDEDAW
3D structure
PDB1rkc Vinculin activation by talin through helical bundle conversion
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S11 I12 V16 Q19 I20 L23 P43 A46 V47 A50 L54 V57 T61 R105 S112 F126 K133 S11 I12 V16 Q19 I20 L23 P43 A46 V47 A50 L54 V57 T61 R105 S112 F126 K133
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0015629 actin cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rkc, PDBe:1rkc, PDBj:1rkc
PDBsum1rkc
PubMed14702644
UniProtP18206|VINC_HUMAN Vinculin (Gene Name=VCL)

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