Structure of PDB 1rjn Chain A

Receptor sequence
>1rjnA (length=259) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
DNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTV
DELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQARAGRLHIL
EVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDAD
VGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHA
ELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAY
MTDEAVEGR
3D structure
PDB1rjn Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 H135 G161 S164 D185 S190 D192 G193 A279
Catalytic site (residue number reindexed from 1) G89 H98 G124 S127 D148 S153 D155 G156 A242
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EP1 A R202 V204 G205 R165 V167 G168
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rjn, PDBe:1rjn, PDBj:1rjn
PDBsum1rjn
PubMed16131752
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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