Structure of PDB 1rjm Chain A

Receptor sequence
>1rjmA (length=239) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
NPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNAFRPHTVD
ELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGHILEVQRLIRFM
PKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYG
SAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQW
AAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRL
3D structure
PDB1rjm Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G105 H135 G161 S164 D185 D192 G193 A279
Catalytic site (residue number reindexed from 1) G88 H89 G115 S118 D139 D146 G147 A233
Enzyme Commision number 4.1.3.36: 1,4-dihydroxy-2-naphthoyl-CoA synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EP1 A R202 V204 G205 R156 V158 G159
Gene Ontology
Molecular Function
GO:0008935 1,4-dihydroxy-2-naphthoyl-CoA synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009234 menaquinone biosynthetic process
GO:0034214 protein hexamerization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rjm, PDBe:1rjm, PDBj:1rjm
PDBsum1rjm
PubMed16131752
UniProtP9WNP5|MENB_MYCTU 1,4-dihydroxy-2-naphthoyl-CoA synthase (Gene Name=menB)

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