Structure of PDB 1rgo Chain A

Receptor sequence

>1rgoA (length=70) Species: 9606 (Homo sapiens)

STRYKTELCRPFEESGTCKYGEKCQFAHGFHELRSLTRHPKYKTELCRTF
HTIGFCPYGPRCHFIHNADE

3D structure

• PDB: 1rgo Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.
• Chain: A
• Resolution: N/A

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R153 K155 T156 E157 L158 R160 K169 Y170 K173 C174 Q175 F176 H189 K191 K193 T194 E195 L196 R198 Y208 R211 C212 H213 F214	R3 K5 T6 E7 L8 R10 K19 Y20 K23 C24 Q25 F26 H39 K41 K43 T44 E45 L46 R48 Y58 R61 C62 H63 F64
BS02	ZN	A	C159 C168 C174 H178	C9 C18 C24 H28
BS03	ZN	A	C197 C206 C212 H216	C47 C56 C62 H66

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0046872 metal ion binding

External links

• PDB: RCSB:1rgo, PDBe:1rgo, PDBj:1rgo
• PDBsum: 1rgo
• PubMed: 14981510
• UniProt: P47974|TISD_HUMAN mRNA decay activator protein ZFP36L2 (Gene Name=ZFP36L2)