Structure of PDB 1rf8 Chain A

Receptor sequence
>1rf8A (length=213) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MSVEEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLWYTKP
AVDKSESWSDLLRPVTSFQTVEEFWAIIQNIPEPHELPLKSDYHVFRNDV
RPEWEDEANAKGGKWSFQLCGKGADIDELWLCTLLAVIGETIDEDDSQIN
GVVLSIRKGGNKFALWTKCEDKEPLLRIGGKFKQVLKLTDDGHLEFFPHC
SANGRHPQPSITL
3D structure
PDB1rf8 Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E.
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTN A E128 C132 E128 C132
BS02 MTN A C200 N203 C200 N203
BS03 M7G A W58 E103 W104 E105 W58 E103 W104 E105
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0098808 mRNA cap binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0051726 regulation of cell cycle
GO:1901195 positive regulation of formation of translation preinitiation complex
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0010494 cytoplasmic stress granule
GO:0016281 eukaryotic translation initiation factor 4F complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:1rf8, PDBe:1rf8, PDBj:1rf8
PDBsum1rf8
PubMed14675538
UniProtP07260|IF4E_YEAST Eukaryotic translation initiation factor 4E (Gene Name=CDC33)

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