Structure of PDB 1rdt Chain A

Receptor sequence
>1rdtA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVEPDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAI
FDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREK
VYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT
PIDTFLMEMLE
3D structure
PDB1rdt Structure-based design of potent retinoid X receptor alpha agonists.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 K284 L294 V298 L301 R302 F450 E453 V35 K39 L49 V53 L56 R57 F205 E208
BS02 L79 A I268 A272 Q275 W305 L309 F313 R316 L326 A327 V342 I345 I23 A27 Q30 W60 L64 F68 R71 L81 A82 V97 I100 MOAD: Ki=6nM
PDBbind-CN: -logKd/Ki=6.70,Ki=200nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:1rdt, PDBe:1rdt, PDBj:1rdt
PDBsum1rdt
PubMed15056000
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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