Structure of PDB 1rdr Chain A

Receptor sequence
>1rdrA (length=316) Species: 12081 (Human poliovirus 1 Mahoney) [Search protein sequence]
VGYPIINAPSKTKLEPSAFHYVFEGVITEVDEYMKEAVDHYAGQLMSLDI
NTEQMCLNDSVAMRMAFGNLYAAFHKNPGVITGSAVGCDPDLFWSKIPVL
MEEKLFAFDYTGYDASLSPAWFEALKMVLEKIGFGDRVDYIDYLNSGTSI
FNSMINNLIIRTLLLKTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQ
SGKDYGLTMTPADKSATFETVTWENVTFLKRFFRADEKYPFLIHPVMPMK
EIHESIRWTKDPRNTQDHVRSLCLLAWHNGEEEYNKFLAKIRSVPIGRAL
LLPEYSTLYRRWLDSF
3D structure
PDB1rdr Structure of the RNA-dependent RNA polymerase of poliovirus.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D233 D329 D109 D184
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1rdr, PDBe:1rdr, PDBj:1rdr
PDBsum1rdr
PubMed9309225
UniProtP03300|POLG_POL1M Genome polyprotein

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