Structure of PDB 1r6n Chain A

Receptor sequence
>1r6nA (length=196) Species: 10580 (human papillomavirus 11) [Search protein sequence]
HEAIAKRLDACQDQLLELYEENSIDIHKHIMHWKCIRLESVLLHKAKQMG
LSHIGLQVVPPLTVSETKGHNAIEMQMHLESLAKTQYGVEPWTLQDTSYE
MWLTPPKRCFKKQGNTVEVKFDGCEDNVMEYVVWTHIYLQDNDSWVKVTS
SVDAKGIYYTCGQFKTYYVNFNKEAQKYGSTNHWEVCYGSTVICSP
3D structure
PDB1r6n Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 434 A H32 W33 L94 Q95 S98 Y99 E100 H32 W33 L94 Q95 S98 Y99 E100 MOAD: Kd=40nM
PDBbind-CN: -logKd/Ki=7.40,Kd=40nM
BS02 434 A W33 T63 V64 T67 K68 N71 W33 T63 V64 T67 K68 N71 MOAD: Kd=40nM
PDBbind-CN: -logKd/Ki=7.40,Kd=40nM
BS03 ALQ A L15 L16 H32 L15 L16 H32
Gene Ontology
Biological Process
GO:0006275 regulation of DNA replication
GO:0006355 regulation of DNA-templated transcription
GO:0016032 viral process

View graph for
Biological Process
External links
PDB RCSB:1r6n, PDBe:1r6n, PDBj:1r6n
PDBsum1r6n
PubMed14634007
UniProtP04015|VE2_HPV11 Regulatory protein E2 (Gene Name=E2)

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