Structure of PDB 1r6g Chain A

Receptor sequence
>1r6gA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
ELQKSIGKKPEPTDEEWELIKTVTEAHVATNARKFLPEDIGQVDLEAFSH
FTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRY
DPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVA
LLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKL
LMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB1r6g Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 442 A F272 I276 A279 R282 M313 R320 L330 N331 G345 L346 H435 R438 F439 M442 F455 F51 I55 A58 R61 M92 R99 L109 N110 G124 L125 H214 R217 F218 M221 F234 PDBbind-CN: -logKd/Ki=9.21,IC50=0.62nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1r6g, PDBe:1r6g, PDBj:1r6g
PDBsum1r6g
PubMed15177471
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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